Receiving professional help to recover from Vicodin addiction is vitally important. Usually, it takes a customized detox & Vicodin treatment program that includes medications Buprenorphine and Naltrexone to manage withdrawal symptoms successfully. Buprenorphine activates the same receptors in the brain as Vicodin, releasing dopamine and relieving symptoms of withdrawal. Naltrexone reduces cravings and also blocks the effects of Vicodin to help prevent relapse.